- ADEVL
Alzheimer's Disease Eval, CSF
Specimen:
Test Code
ADEVL
Specimen Name
Alzheimer's Disease Eval, CSF
Collect
Sterile Container
Submit
2.5 mL (Min 1.5 mLs) CSF Refrigerated
Special Handling
Must be collected in Sarstedt CSF False Bottom Tube 63.614.625 (2.5 mL); also acceptable Sarstedt 72.703.600 (1.5 mL) or Sarstedt 72.694.600 (2 mL). 1. Perform lumbar puncture and discard the first 1 to 2 mL of cerebrospinal fluid (CSF). 2. Collect CSF directly into one of the listed collection tubes until the tube is at least 50% full.* 3. Send CSF specimen in original collection tube. Do not aliquot. Note: Polystyrene collection tubes are not acceptable. Exposure of CSF to polystyrene tubes may result in falsely low Abeta42 concentrations. For more information see Cautions. *The Alzheimer's Association consensus protocol for handling of CSF for clinical measurements of Abeta42 and tau recommends using the drip method for CSF collection and directly collecting into a low-bind polypropylene tube. Although some clinicians prefer the syringe pull method due to speed of collection, the drip method reduces the risk of Abeta42 binding to the plastic of any syringe used.
Rejection Criteria
Gross hemolysis, lipemia, icterus
Stability
Ambient 12 hours; Refrigerated 14 days; Frozen 60 days
Methodology
Electrochemiluminescent Immunoassay (ECLIA)
Performed
Tuesday/Thursday/Friday
Reported
2-8 days
CPT Codes
- 82234
- 84393
- 84394
Components
Includes: Beta-Amyloid 42 (1-42)(Abeta42), Phosphorylated Tau (p-Tau181)
Additional Information
Collection instruction form if needed. https://www.mayocliniclabs.com/-/media/it-mmfiles/Special-Instructions/4/0/F/Spinal-Fluid-Specimen-Collection-Instructions-for-Alzheimer-Disease-Evaluation Fill out form and send with specimen. https://www.mayocliniclabs.com/-/media/it-mmfiles/Special-Instructions/C/1/5/neurology-request-form
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