Bleeding Diathesis Profile, Limited

Optical Clot-Based; Latex Immunoassay (LIA); Clauss

Initial testing includes prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin time (bovine), fibrinogen, D-dimer, coagulation factor VIII activity assay, coagulation factor IX assay, von Willebrand factor antigen (VWF Ag), VWF activity, factor XIII screen, and limited bleed profile interpretation.

Patient Preparation: 1. Patient should not be receiving anticoagulant treatment (eg, warfarin, heparin). Treatment with heparin causes false-positive results of in vitro coagulation testing for lupus anticoagulant. Warfarin treatment may impair ability to detect the more subtle varieties of lupus-like anticoagulants. If not possible for medical reasons, note on request. a. If medically feasible, for 4 to 6 hours before specimen collection, do not administer intravenous heparin. b. If medically feasible, for 10 to 14 days before specimen collection, do not administer subcutaneous heparin or warfarin. 2. Patient should not be receiving fibrinolytic agents (streptokinase, urokinase, tissue plasminogen activator [tPA]). 3. It is recommended that specimens be collected pretransfusion. If patient has been transfused, a specimen should not be collected for 48 hours.